Luca Signorelli (c. 1450—16 October 1523) was an Italian Renaissance painter who was noted in particular for his ability as a draftsman and his use of foreshortening. His massive frescoes of the Last Judgment (1499–1503) in Orvieto Cathedral are considered his masterpiece.

He was born Luca d'Egidio di Ventura in Cortona, Tuscany (some sources call him Luca da Cortona). The precise date of his birth is uncertain, but birth dates between 1441 and 1445 have been proposed. He died in 1523 in his native Cortona, where he is buried. He was likely between seventy-eight and eighty-two years old. He is considered to be part of the Tuscan school, although he also worked extensively in Umbria and Rome.